Sarcomeric/mitochondrial Creatine Kinase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• reversibly catalyzes transfer of phosphate between ATP & various phosphogens (e.g. creatine phosphate)
• creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain & spermatozoa
• binds cardiolipin
  

• ATP + creatine = ADP + phosphocreatine

Structure

• octamer composed of four CKMT2 homodimers
• belongs to the ATP:guanido phosphotransferase family

Compartment

• mitochondrial inner membrane; intermembrane side

Expression

• sarcomere-specific
• found only in heart & skeletal muscles

More General Terms

• creatine kinase
• mitochondrial membrane protein

Internet Database

UniProt: [1]
Kegg: [2]
OMIM: 123295
Prosite: [3]
UniProt: [4]

References

UniProt [5]

sarcomeric/mitochondrial creatine kinase (S-mtCK, CKMT2)