Salsalate

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradenames: Salflex, Disalcid.

Indications

• temporary relief from minor aches & pains, fever & inflammation
• rheumatoid arthritis
• osteoarthritis
• lowers hemoglobin A1c in diabetes mellitus type-2 [4]

Dosage

• 750 mg PO QID, max 3 g/day

• Tabs: 500, 750 mg.

Pharmacokinetics

• bioavailability is dependent upon dose form
• drug eliminated primarily by the kidneys
  

• elimination via kidney
• 1/2life = 1 hours

Adverse-effects

• common (> 10%)

• nausea, heartburn, epigastric pain, dyspepsia

• less common (1-10%)

• weakness, tiredness, hemolytic anemia, rash, dyspnea, gastrointestinal ulceration, anaphylactic shock

• uncommon (< 1%)

• insomnia, nervousness, jitters, leukopenia, thrombocytopenia, hepatotoxicity, bronchospasm, iron-deficiency anemia, renal insufficiency, occult bleeding, hepatotoxicity

• other

• may be associated with Reye's syndrome when used by children or teenagers with influenza or chicken pox
• does not appear to affect platelet aggregation
  
• drug adverse effects of NSAIDs

Drug-interactions

• corticosteroids

• increase clearance of salicylates
• may increase nephrotoxicity

• ACE inhibitors: decreased antihypertensive effect
• warfarin: minimal prolonged bleeding time
• salsalate increases methotrexate levels & possible toxicity
  
• drug interaction(s) of lithium carbonate with NSAIDs
• drug interaction(s) of beta-adrenergic receptor antagonists with salicylate
• drug interaction(s) of salicylates with sulfonylureas
• drug interaction(s) of NSAIDs with SSRIs
• drug interaction(s) of aspirin with NSAIDs
• drug interaction(s) of NSAIDs with beta blockers
• drug interaction(s) of NSAIDs with ARBs
• drug interaction(s) of NSAIDs with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
• drug interaction(s) of NSAIDs & loop diuretics
• drug interaction(s) of NSAIDs & aspirin

Mechanism-of-action

• analgesic, antipyretic, anti-inflammatory & anti- rheumatic effects

More General Terms

• salicylate
• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 5161

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
4. Goldfine AB et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial. Ann Intern Med 2010 Mar 16; 152:346. PMID: [1]

salsalate (Salflex, Disalcid, sasapyrine)