S Adenosylmethionine Synthetase Gamma

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 More General Terms 4 Internet Database 5 References

Function

• catalytic subunit of methionine adenosyltransferase 2
• catalyzes the formation of S-adenosylmethionine from methionine & ATP
• biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1, context: activated methyl cycle
  

• ATP + L-methionine + H2O
• <-->
• phosphate + diphosphate + S-adenosyl-L-methionine
  
• Cofactor:

• binds 2 divalent ions per subunit. Mg+2 or cobalt
• binds 1 K+ per subunit ( putative)

Structure

• heterotetramer composed of 2 catalytic alpha subunits (alpha & alpha') (MAT2A) & 1 copy of beta subunit ( MAT2B)
• amino-acid biosynthesis; S-adenosyl-L-methionine
• the alpha' subunit is a post-translationally modified version of MAT2A
• belongs to the AdoMet synthetase family

More General Terms

• methionine adenosyl transferase
• enzyme catalytic subunit

Internet Database

Kegg: [1]
OMIM: 601468
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

UniProt [5]

S-adenosylmethionine [SAM] synthetase-gamma (methionine adenosyltransferase 2 subunit alpha MAT2A)