S Adenosylmethionine Synthetase Alpha/beta

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Expression 4 Pathology 5 More General Terms 6 Internet Database 7 References

Function

• catalyzes the formation of S-adenosylmethionine from methionine & ATP
• amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis
• S-adenosyl-L-methionine from L-methionine: step 1/1 context: activated methyl cycle
  

• ATP + L-methionine + H2O
• <-->
• phosphate + diphosphate + S-adenosyl-L-methionine
  
• Cofactor:

• binds 2 divalent ions per subunit, Mg+2 or cobalt
• binds 1 K+ per subunit ( putative)

Structure

• homotetramer ( MAT-I) or homodimer ( MAT-III)
• belongs to the AdoMet synthetase family

Expression

• expressed in liver

Pathology

• defects in MAT1A are a cause of a form of hypermethioninemia

More General Terms

• methionine adenosyl transferase

Internet Database

UniProt: [1]
Kegg: [2]
OMIM: 250850
Prosite: [3]
Prosite: [4]

References

1. UniProt [5]
2. GeneReviews [6]

S-adenosylmethionine [SAM] synthetase-alpha/beta (S-adenosylmethionine synthetase isoform type-1, AdoMet synthetase 1, MAT1A, AMS1, MATA1, MAT-I/III)