S Adenosylmethionine
From Anvita Health Wiki
Contents |
Function
- S-adenosylmethionine provides a methyl group in synthesis of:
Pharmacology
- SAMe
Indications
- * Preliminary suggest SAM-e may be as beneficial as NSAIDs for treatment of osteoarthritis [3]
Contraindications
- not effective for bipolar disorder
- not effective for hyperhomocysteinemia [4]
Dosage
- 400 mg PO BID
- 800 mg PO BID ( depression)
- parenteral form used for depression [2]
- discontinue >= 14 days prior to surgery [4]
Adverse-effects
- generally well tolerated
- primarily gastrointestinal distress
- insomnia [4]
- dizziness [4]
- xerostomia [4]
- headache [4]
- restlessness [4]
- potential to cause agitation, mania, or hypomania via alterations in neurotransmitter levels
Drug-interactions
- antidepressants
- St John's wort
- antiplatelet agents including NSAIDs [4]
- anticoagulants
Mechanism-of-action
- increases plasma cortisol & ACTH
- reduces plasma prolactin
- increases catechol-O-methyltransferase ( COMT) activity
- inhibits MAO-B in the brain
- enhances MAO activity in heart & brain
- enhances proteoglycan production by chondrocytes
- anti-inflammatory properties
- analgesic properties
- serotonin agonist
More General Terms
Additional Terms
- carnitine biosynthesis
- catecholamine metabolism
- methionine adenosyltransferase, S-adenosylmethionine [SAM] synthetase or ADOMET synthetase
- methionine metabolism (trans-sulfuration pathway)
Internet Database
PubChem: 34755
PubChem: 5136
PubChem: 34756
PubChem: 1079
PubChem: 446104
References
- Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 582
- Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004; 7th edition 2010
- Prescriber's Letter 10(5):27 2003
- Geriatrics at your Fingertips, 13th edition, 2011 Reuben DB et al (eds) American Geriatric Society
