Ryanodine Receptor

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Structure 4 Expression 5 Pharmacology 6 More General Terms 7 Additional Terms 8 References

More Specific Terms

• ryanodine receptor 1; RYR-1; RyR1; skeletal muscle-type ryanodine receptor; skeletal muscle Ca+2 release channel (RYR1, RYDR)
• ryanodine receptor 2; RYR-2; RyR2; hRYR-2; cardiac muscle-type ryanodine receptor; cardiac muscle ryanodine receptor-Ca+2 release channel (RYR2)
• Ryanodine receptor 3; RYR-3; RyR3; brain-type ryanodine receptor; brain ryanodine receptor-Ca+2 release channel (RYR3 HBRR)

Function

• Ca+2 channel
• release Ca+2 from intracellular stores
• signal transduction
• excitation- contraction
• excitation- secretion coupling
• hysiological modulators:

• Ca+2
• kinases
• phosphatases
• redox state
• energy charge, ATP

Structure

• tetramer

Expression

• RyR1 is expressed mainly skeletal muscle
• RyR2 is expressed in cardiac muscle
• RyR3 is expressed in nervous system

Pharmacology

• pharmacological regulators:

• caffeine
• dantrolene
• ruthenium red
• heavy metals
• ryanodine

More General Terms

• transmembrane 12 protein
• oligomerizing protein
• ionotropic receptor
• Ca+2 channel

Additional Terms

• ryanodine

References

1. Butanda-Ochoa A, Hojer G, Morales-Tlalpan V, Diaz-Munoz M. Recognition and activation of ryanodine receptors by purines. Curr Med Chem. 2006;13(6):647-57. Review. PMID: [1]
2. Wikipedia; Note: Ryanodine receptor entry [2]

ryanodine receptor (RyR)