Ring Finger Protein 34

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Expression 4 Notes 5 More General Terms 6 Internet Database 7 References

Function

• E3 ubiquitin protein ligase activity
• regulates levels of CASP8 & CASP10 by targeting them for proteasomal degradation
• protects cells against apoptosis induced by TNF.
• binds phosphatidylinositol-5-phosphate & phosphatidylinositol-3-phosphate.
• interacts with DNAJA3 ( putative), CASP8, CASP10
• auto- ubiquitinated ( in vitro)
• proteolytically cleaved by caspases after induction of apoptosis by TNF

Compartment

• nucleus, nucleoplasm, nuclear speckle
• intracellular membrane, peripheral membrane

Expression

• ubiquitous
• expressed in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon, leukocytes

Notes

• originally isolated as potential interaction partner of mitochondrial protein DNAJA3, but the 2 proteins are NOT in the same cellular compartments

More General Terms

• ring finger protein
• E3 ubiquitin ligase

Internet Database

OMIM: 608299
Prosite: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

UniProt [5]

RING finger protein 34 (RING finger protein RIFF, FYVE-RING finger protein Momo, human RING finger homologous to inhibitor of apoptosis protein, hRFI, caspases-8 & -10-associated RING finger protein 1, CARP-1, caspase regulator CARP1, RNF34)