Ring Finger Protein 34
From Anvita Health Wiki
Contents |
Function
- E3 ubiquitin protein ligase activity
- regulates levels of CASP8 & CASP10 by targeting them for proteasomal degradation
- protects cells against apoptosis induced by TNF.
- binds phosphatidylinositol-5-phosphate & phosphatidylinositol-3-phosphate.
- interacts with DNAJA3 ( putative), CASP8, CASP10
- auto- ubiquitinated ( in vitro)
- proteolytically cleaved by caspases after induction of apoptosis by TNF
Compartment
- nucleus, nucleoplasm, nuclear speckle
- intracellular membrane, peripheral membrane
Expression
- ubiquitous
- expressed in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon, leukocytes
Notes
- originally isolated as potential interaction partner of mitochondrial protein DNAJA3, but the 2 proteins are NOT in the same cellular compartments
More General Terms
Internet Database
OMIM: 608299
Prosite: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]
References
UniProt [5]
