Replication Factor C

From Anvita Health Wiki

Contents 1 Function 2 Subunits 3 More General Terms 4 Additional Terms 5 References

Function

• elongation of primed DNA templates by DNA polymerase delta & DNA polymerase epsilon requires the action of the accessory proteins PCNA & replication factor-C (activator 1)
• complex containing RFC1 forms a complex with PCNA in the presence of ATP stimulating ATPase activity
• complex containing RAD17 does not interact with PCNA

Subunits

• heteropentamer of subunits: replication factor C subunit 1 ( RFC1) replication factor C subunit 2 ( RFC2) replication factor C subunit 3 ( RFC3) replication factor C subunit 4 ( RFC4) replication factor C subunit 5 ( RFC5)
• RFC2, RFC2, RFC4, & RFC5 may complex with either RFC1 or RAD17 [2]
• RFC2, RFC2, RFC4, & RFC5 may complex with CTF18, CTF8, & DCC1 in the CTF18-RFC complex [3]

More General Terms

• adenosine triphosphatase (ATPase)
• DNA-binding protein
• nuclear protein
• multisubunit protein

Additional Terms

• CTF18-replication factor C
• proliferating cell nuclear antigen (PCNA)

References

1. Linn S How many pols does it take to replicate nuclear DNA? Cell 66:185 1991 PMID: [1]
2. UniProt [2]

replication factor-C