Renalase

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 Alternative-splicing 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• FAD-dependent amine oxidase secreted by the kidney
• circulates in blood & modulates cardiac function & systemic blood pressure
• degrades catecholamines

• dopamine, norepinephrine, epinephrine in vitro

• lowers blood pressure by decreasing cardiac contractility & heart rate & preventing a compensatory increase in peripheral vascular resistance
  

• Cofactor: FAD

Compartment

• secreted into blood by the kidney

Alternative-splicing

• named isoforms=2

Expression

• expressed in the kidney > heart, skeletal muscle, small intestine

Pathology

• plasma concentration is markedly diminished in patients with end-stage renal disease

More General Terms

• amine oxidoreductase

Internet Database

UniProt: [1]

References

UniProt [2]

renalase (C10orf59)