Renal Osteodystrophy

From Anvita Health Wiki

Contents 1 Etiology 2 Pathology 3 Management 4 More General Terms 5 Additional Terms 6 References

Etiology

• chronic renal failure

Pathology

• 4 components:

• osteitis fibrosa cystica

• hyperparathyroidism
• osteoclastic overactivity

• osteomalacia

• 1,25-dihydroxy- vitamin D deficiency
• increased osteoid formation within bone

• osteoporosis
• growth retardation

• pathophysiology

• phosphate retention
• stimulates parathyroid hormone
• decrease in urinary calcium
• bone is often poorly responsive to PTH in chronic renal failure
• 1,25 dihydroxyvitamin D deficiency leads to:

• phosphate retention
• increasing PTH

Management

• renal diet: restriction of phosphate-rich foods
• intestinal phosphate binders

• calcium acetate
• calcium carbonate

• calcitriol

More General Terms

• osteodystrophy
• chronic kidney disease (CKD)

Additional Terms

• hyperparathyroidism
• osteitis fibrosa cystica
• osteomalacia
• osteoporosis

References

1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 617
2. Renal Osteodystrophy [1]

renal osteodystrophy