Radical S Adenosyl Methionine Domain Containing Protein 2

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• role in antiviral defense
• inhibits infection by human cytomegalovirus, down-regulating expression of a number of viral proteins including glycoprotein B, pp28 & pp65
• inhibits replication of hepatitis C virus

• Cofactor:

• binds 1 4Fe-4S cluster
• cluster is coordinated with 3 cysteines & an exchangeable S-adenosyl-L-methionine

Structure

• belongs to the RSAD2 family

Compartment

• endoplasmic reticulum, Golgi apparatus
• probably associates with the cytosolic side of the endoplasmic reticulum
• infection with human cytomegalovirus (HCMV) causes relocation to the Golgi & to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B & pp28

Expression

• induced by LPS, interferon alpha &, to a lesser extent, interferon gamma
• little or no induction by interferon gamma is observed in monocytic cell lines
• induced by infection with human cytomegalovirus (HMCV), hepatitis C virus, yellow fever virus & Sendai virus
• induction by HMCV is mediated by glycoprotein B

Pathology

• expressed in the endothelium of atherosclerotic arteries but not in normal arteries (at protein level)

More General Terms

• uncharacterized protein

Internet Database

OMIM: 607810
UniProt: [1]

References

UniProt [2]

radical S-adenosyl methionine domain-containing protein 2 (virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible, viperin, cytomegalovirus-induced gene 5 protein, RSAD2, CIG5)