Punica Gratum

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Pharmacokinetics 4 Drug-interactions 5 Mechanism-of-action 6 More General Terms 7 References

Introduction

• contains ellagitannins, including punicalagin largest polyphenol MW 1084 g/m

Indications

• cancer prevention? [4]

• prevention of androgen-independent prostate cancer? [9]

• autoimmune disease prevention? [5]
• obesity ? [6]

Pharmacokinetics

• inhibits cyt P450 3A4 & cyt P450 2D6

Drug-interactions

• may increase levels of any drug metabolized by cyt P450 3A4 or cyt P450 2D6 (i.e. macrolides, Ca+ channel blockers, metoprolol, antiviral protease inhibitors, statins)

Mechanism-of-action

• antioxidant properties
• inhibits NF-kappa-B [9]
• inhibits angiogenesis [8]

More General Terms

• pharmacy
• fruit

References

1. Schwartz S Human intestinal uptake of carotenoid phytonutrients Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA
2. Prescriber's Letter 13(2): 2006 Detail-Document#: [1] (subscription needed) [2]
3. Prescriber's Letter 13(12): 2006 Health benefits of tropical fruit juices Detail-Document#: [3] (subscription needed) [4]
4. Khan N, Afaq F, Kweon MH, Kim K, Mukhtar H. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res. 2007 Apr 1;67(7):3475-82. Epub 2007 Mar 27. PMID: [5]
5. Borhani Haghighi A, Bagheri M. Pomegranate juice may be a potential addition to anti-Behcet armamentarium: a hypothesis. Clin Rheumatol. 2007 Apr 4; [Epub ahead of print] PMID: [6]
6. Lei F, Zhang XN, Wang W, Xing DM, Xie WD, Su H, Du LJ. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int J Obes (Lond). 2007 Feb 13; [Epub ahead of print] PMID: [7]
7. Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007 Jan 19;109(2):177-206. Epub 2006 Sep 10. Review. PMID: [8]
8. Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM et al Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol. 2008 Feb;32(2):475-80. PMID: [9]
9. Rettig MB et al Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-KB-dependent mechanism. Mol Cancer Ther 2008;7(9). September 2008 PMID: [10]
10. Jurenka JS. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008 Jun;13(2):128-44. PMID: &dopt=Abstract

Punica gratum (pomegranate, Pom Wonderful)