Pseudo Porphyria Cutanea Tarda

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Contents 1 Introduction 2 Etiology 3 Pathology 4 Clinical-manifestations 5 More General Terms 6 Additional Terms 7 References

Introduction

• A distinct syndrome with blisters & erosions indistinguishable from porphyria cutanea tarda ( PCT).

Etiology

• drugs: naproxen, ibuprofen, tetracyclines, nalidixic acid, dapsone, amiodarone, bumetanide, furosemide, cyclosporine, etretinate, chlorthalidone, diazide, pyridoxine
• chronic renal failure with hemodialysis
• tanning salon radiation (visible & UV-A)
• associated disorders

• hepatoma
• lupus erythematosus
• sarcoidosis
• Sjogren's syndrome
• hepatitis C

Pathology

• subepidermal bullae
• little or no dermal inflammation

Clinical-manifestations

• vesicles & tense bullae on normal-appearing skin

• painful erosions from easily traumatized bullae
• atrophic scars at sites of erosions
• distibution: dorsa of hands & feet, nose

• fragile skin

More General Terms

• skin disease (dermatologic disorder, dermatopathy, dermatosis)

Additional Terms

• porphyria cutanea tarda (PCT)

References

1. Color Atlas & Synopsis of Clinical Dermatology, Common & Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 256
2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 179

pseudo-porphyria cutanea tarda (PCT)