Protein S

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Function 3 Expression 4 Pathology 5 More General Terms 6 Additional Terms 7 Internet Database 8 References

More Specific Terms

• protein-S alpha
• protein-S beta

Function

• vitamin K-dependent binding protein
• cofactor for protein C
• binds C4b-binding protein; 50% is protein bound
• only free form of protein S has biological activity

Expression

• plasma activity may be reduced as a result of acute thrombosis
• anticoagulation may lower activity of protein S in plasma

Pathology

• individuals with heterozygous protein C deficiency often develop thromboembolic disease before age 30

More General Terms

• coagulation factor
• anticoagulant

Additional Terms

• coagulation cascade
• protein S activity in plasma (protein S assay)
• protein S deficiency

Internet Database

UniProt: [1]
OMIM: 176880

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

protein-S