Protein Kinase C Beta 1

From Anvita Health Wiki

Contents 1 Function 2 Compartment 3 More General Terms 4 Internet Database

Function

• Ca+2-activated, phospholipid-dependent, Ser- & Thr- specific enzyme
• component of the NF-kappa-B signaling axis responsible for survival & activation of B-cells after BCR cross-linking
• phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate; subsequent autophosphorylation of Thr-642 maintains catalytic competence, & autophosphorylation on Ser-661 appears to release the kinase into the cytosol
• similarly, isoform beta-II is autophosphorylated on Thr-640 & Ser-659, subsequent to phosphorylation on Thr-500
• autophosphorylated on other sites i.e in the N-terminal & hinge regions have no effect on PKC activity
• interacts with PDK1, PRKCBP1
  

• Cofactor: binds 3 Ca+2 per subunit; binds via C2 domain

Compartment

• cytoplasm, peripheral membrane

More General Terms

• protein kinase C-beta (PKC-II, PRKCB1, PKCB, PRKCB)

Internet Database

UniProt: [1]
Entrez gene: 5579
Kegg: [2]
OMIM: 176970
Prosite: [3]
Prosite: [4]
Prosite: [5]
Prosite: [6]
Prosite: [7]
Prosite: [8]
Prosite: [9] protein kinase C-beta 1 (PKC-IIa, PRKCB1)