Protein C Assay

From Anvita Health Wiki

Contents 1 Reference-interval 2 Increases 3 Decreases 4 Methods 5 Specimen 6 More General Terms 7 Additional Terms 8 References

Reference-interval

• 70-140% of normal reference activity
• 2.82-5.65 ug/mL

Increases

• pharmaceutical agents:

• chemical interferences

• heparin, warfarin

• in vivo effects

• oral contraceptives, stanozolol

Decreases

• pharmaceutical agents

• chemical interferences

• high factor VIII activity

• clinical disorders: hypercoagulability

• congenital deficiency

• type 1: low functional & antigenic levels
• type 2: low functional & normal antigenic levels

• acquired deficiency

• hepatic disorders

Methods

• functional* clotting assay based on anticoagulant activity
• rocket immunoelectrophoresis
• enzyme-linked immunosorbant assays ( ELISA)

• * NOT useful if patient is anticoagulated

Specimen

• plasma ( citrate)
• stable at room temperature for 8 hours
• stable at -20 degrees C for 1 month

More General Terms

• clinical hematology test

Additional Terms

• activated protein C (APC) resistance assay
• protein C antigen in plasma
• protein C deficiency
• protein-C (autoprothrombin IIA)

References

1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

protein C in plasma (protein C assay)