Protein C Activated

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Contents 1 More Specific Terms 2 Function 3 Expression 4 Pharmacology 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• drotrecogin alpha (Xigris); recombinant protein C, activated

Function

• vitamin K-dependent serine protease
• proteolytically inactivates coagulation factors: factor Va & factor VIIIa
• stimulates fibrinolysis
• activity is enhanced by protein S
• cleavage of factor Va by activated protein C occurs at amino acid residue 506, the site of factor V Leiden mutation

Expression

• plasma activity may be reduced as a result of acute thrombosis
• anticoagulation lowers activity of protein C in plasma.

Pharmacology

• recombinant activated protein C, see drotrecogin alpha ( Xigris)

More General Terms

• coagulation factor
• serine protease trypsin family
• anticoagulant

Additional Terms

• coagulation cascade
• drotrecogin alpha (Xigris); recombinant protein C, activated
• protein C deficiency
• protein C in plasma (protein C assay)
• protein-C (autoprothrombin IIA)
• protein-C inhibitor or plasminogen activator inhibitor-3 (PAI3)

References

1. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992 May;6(8):2561-7. Review. PMID: [1]
2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

protein C, activated