Proparacaine

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 More General Terms 6 Internet Database 7 References

Introduction

• Tradenames: Ophthaine, Ophthetic.

Indications

• anesthesia for tonometry, gonioscopy, suture removal from cornea
• removal of corneal foreign body, cataracts extraction, glaucoma surgery, short operative procedures involving the cornea & conjunctiva

• Never prescribe due to corneal toxicity with repeated use.

Dosage

• ophthalmic surgery: 1 drop 0.05% solution every 5-10 minutes for total of 5-7 doses
• tonometry, gonioscopy, suture removal: 1-2 drops of 0.o5% solution in eye just prior to the procedure

• Solution: 0.05% (15 mL).

Adverse-effects

• less common (1-10%)

• burning, stinging, redness

• uncommon (< 1%)

• CNS depression, blurred vision, arrhythmias, increased sweating, lacrimation, allergic contact dermatitis, irritation, sensitization, keratitis, iritis, erosion of corneal epithelium, conjunctival congestion & hemorrhage, corneal opacification

More General Terms

• ophthalmic agent (eyedrops)

Internet Database

PubChem: 4935
PubChem: 517321
PubChem: 22169

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

proparacaine; proxymetacaine (Ophthaine, Ophthetic, Keracaine)