Potassium Sparing Diuretic

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Contents 1 More Specific Terms 2 Indications 3 Monitor 4 Drug-interactions 5 Mechanism-of-action 6 More General Terms 7 References

More Specific Terms

• amiloride (Midamor, Amipramidin, Modamide)
• epleronone (Inspra)
• spironolactone (Aldactone)
• triamterene (Dyrenium)

Indications

• treatment of hypertension

• weak blood pressure lowering effects in most patients

• adjunctive treatment of heart failure

Monitor

• serum K+
  
• monitor with potassium-sparing diuretics

Drug-interactions

• hyperkalemia potentiated by concomitant use of

• ACE inhibitors
• NSAIDs
  

• drug interaction(s) of spironalactone with potassium-sparing diuretics
• drug interaction(s) of diuretics with angiotensin II receptor antagonists
• drug interaction(s) of diuretics with ACE inhibitors
• drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
• drug interaction(s) of NSAIDs, diuretics & ACE inhibitors

Mechanism-of-action

• site of action: distal tubule & collecting duct

More General Terms

• diuretic

References

- Prescriber's Letter 16(2): 2008 Comparison of Commonly Used Diuretics Detail-Document#: [1] (subscription needed) [2] K+ sparing diuretic