Potassium Phosphate

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Adverse-effects 4 Drug-interactions 5 More General Terms 6 Internet Database 7 References

Indications

• potassium & phosphate replacement
• acidification of urine
• lowering urinary Ca+2 concentration
• reduce odor & rash caused by ammoniacal urine

Dosage

• IV dosing only for K+ replacement
• give dose based on potassium & phosphate levels
• as urinary tract agent:

• 1000 mg dissolved in 6-8 oz of water QID (with meals & QHS) , Na+ free: 500 mg = 3.67 meq K+

• Injection: 3 mmol phosphate & 4.4 meq K+/ mL (15 mL) 224 mg monobasic (K2HPO4) & 236 mg dibasic (KH2PO4)/ mL must be diluted prior to administration

Adverse-effects

• common (> 10%)

• diarrhea, nausea/vomiting, epigastric pain, flatulence

• less common (1-10%)

• bradycardia, hyperkalemia, local tissue necrosis with extravasation, weakness, dyspnea

• uncommon (< 1%)

• chest pain, arrhythmia, edema, confusion, tetany, pain of extremities, hyperphosphatemia*, hypocalcemia*, alkalosis, abdominal pain, weight gain, throat pain, decreased urine output, phlebitis, paresthesias, paralysis, bone pain, arthralgia, weakness of extremities, dyspnea, thirst

• * phosphate toxicity can result in hypocalcemic tetany

Drug-interactions

• increased effect of digoxin

More General Terms

• salt
• metabolic agent (metabolic modifier)

Internet Database

PubChem: 24506

References

1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 Department of Veterans Affairs, VA National Formulary
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

potassium phosphate (KH2PO4)