Potassium Citrate

From Anvita Health Wiki

Contents 1 Indications 2 Contraindications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 More General Terms 7 Additional Terms 8 Internet Database 9 References

Indications

• hypokalemia associated with metabolic acidosis
• long-term maintenance of alkaline urine
• hypertension ? [3]
• prevention of osteoporosis ? [3]

Contraindications

• hyperkalemia
• conditions predisposing to hyperkalemia

• renal failure
• uncontrolled diabetes
• adrenal insufficiency
• concurrent administration of K+ sparing diuretic

• conditions causing a delay in passage through the GI tract

• delayed gastric emptying
• esophageal compression
• intestinal obstruction or stricture
• concurrent administration of anticholinergic agents

• peptic ulcer disease
• active urinary tract infection

• pregnancy-category :value C
• safety-in-lactation :value ?

Dosage

• 30-100 meq/day

•  : 10 meq

Pharmacokinetics

• elimination :route kidney

Adverse-effects

• hyperkalemia
• metabolic alkalosis
• gastrointestinal mucosal lesions Mechanism:
• increases bone mineral density* [3], citrate contributes ( KCl does not show same effect)
• diminishes systolic & diastolic blood pressure* due to K+ [3]

• * in postmenopausal women

More General Terms

• salt
• metabolic agent (metabolic modifier)

Additional Terms

• citrate (citric acid)
• K+

Internet Database

PubChem: 22470
PubChem: 13344

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Physician's Desk Reference (PDR) 52nd edition, Medical Economics, 1998
3. Jehle S et al, Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia. J Am Soc Nephrol 2006, 17:3213 PMID: [1]

potassium citrate (Urocit K)