Potassium Channel Protein Kv1.3

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Notes 5 More General Terms 6 Internet Database 7 References

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• assumes opened or closed conformation in response to voltage difference across membrane
• forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
• heterotetramer of K+ channel proteins
• binds PDZ domains of DLG1, DLG2 & DLG4 ( putative)

Structure

• the N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• the segment S4 is probably the voltage- sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, A ( Shaker) subfamily

Compartment

• membrane

Notes

• uncertain whether Met-1 or Met-53 is the initiator

More General Terms

• voltage-gated K+ channel alpha subunit
• glycoprotein
• phosphoprotein

Internet Database

UniProt: [1]
Entrez gene: 3738
Kegg: [2]
OMIM: 176263

References

UniProt [3]

K+ voltage-gated channel subfamily A member 3; voltage-gated K+ channel subunit Kv1.3; HPCN3; HGK5; HuKIII; HLK3 (KCNA3, HGK5)