Poliovirus Vaccine Inactivated

From Anvita Health Wiki

Contents 1 Indications 2 Contraindications 3 Dosage 4 Pharmacokinetics 5 Drug-interactions 6 More General Terms 7 Additional Terms 8 References

Indications

• active immunization against poliovirus

Contraindications

• acute febrile illness
• may administer during common cold
• hypersensitivity to streptomycin or neomycin

• pregnancy-category C
• safety in lactation ?

Dosage

• (4 doses)

• Primary immunization: (begin at 6 months of age)

• three 0.5 mL injections SC
• the 1st 2 doses at intervals of 8 weeks
• the 3rd dose 6-12 months after the 2nd dose

• Booster:

• all children who have received 3-dose primary immunization before their 4th birthday should receive a booster of 0.5 mL SC before entering school (4-6 years of age) [3]
• shortest interval after the 3rd dose is 6 months [3]

• Injection:

• suspension of 3 types of poliovirus (1,2 & 3) grown in human diploid cell cultures (0.5 mL)
• the vaccine should be perfectly clear & pink or red in color

Pharmacokinetics

• elimination: liver Adverse reactions:

• most common (1-10%)

• skin rash, fever > 101.3, inflammation at injection site

• uncommon (< 1%)

• dyspnea, erythema, tiredness, weakness, Guillain Barre syndrome, fussiness, sleepiness, crying, decreased appetite

Drug-interactions

• may temporarily suppress tuberculin skin reactivity (4-6 weeks)
• immunosuppressive agents
• immune globulin

More General Terms

• vaccine

Additional Terms

• polio virus

References

1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
2. Department of Veterans Affairs, VA National Formulary
3. Centers for Disease Control (CDC) Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP) Regarding Routine Poliovirus Vaccination MMWR August 7, 2009 / 58(30);829-830 [1]

polio virus vaccine, inactivated (IPOL, IPV, Poliovax, Salk vaccine)