Platelet Disorder

From Anvita Health Wiki

Contents 1 More Specific Terms 2 Etiology 3 Epidemiology 4 Laboratory 5 More General Terms 6 Additional Terms 7 References

More Specific Terms

• acquired platelet aggregation disorder
• Bernard-Soulier disease (giant platelet syndrome, benign Mediterranean macrothrombocytopenia)
• Epstein syndrome
• Glanzmann's thrombasthenia
• gray platelet syndrome
• macrothrombocytopenia with sensorineural deafness
• Sebastian syndrome
• storage pool disease
• thrombocytopenia
• thrombocytosis (thrombocythemia)
• von-Willebrand's disease (vWD)

Etiology

• platelet adhesion defects

• von Willebrand's disease
• Bernard Soulier disease

• platelet aggregation defects

• Glanzmann's thrombasthenia

• platelet release defects

• decreased cyclooxygenase activity

• non-steroidal anti-inflammatory drugs ( NSAIDs) (most common acquired qualititative platelet defect)
• congenital

• granule storage pool defects

• congenital
• acquired

• uremia
• platelet coating

• penicillin
• paraproteins

• platelet coagulant defect

• Scott's syndrome

• disorders associated with thrombocytosis

• essential thrombocythemia
• polycythemia rubra vera

• thrombocytopenia

Epidemiology

• only von-Willebrand's disease is common
• all other platelet disorders (excepting drug induced) are rare

Laboratory

• complete blood count ( CBC)
• bleeding time
• von Willebrand factor ( vWF)
• platelet aggregometry

More General Terms

• hematologic disease (blood disorder, blood dyscrasia)

Additional Terms

• platelet
• platelet count
• thrombocytopenia
• thrombocytosis (thrombocythemia)

References

1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
2. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 321

platelet disorder