Pimecrolimus

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Contents 1 Introduction 2 Indications 3 Dosage 4 Adverse-effects 5 Mechanism-of-action 6 Notes 7 More General Terms 8 Additional Terms 9 References

Introduction

• Tradename: Elidel.

Indications

• topical agent for treatment of mild to moderate eczema

• atopic dermatitis [3,5]

Dosage

• apply BID

• Elidel: 1% pimecrolimus

Adverse-effects

• may cause feeling of skin warmth or burning, esp in 1st few days
• photosensitivity (use sunscreen)
• increased risk of skin cancer [4,6]
  
• drug adverse effects of immunosuppressive agents

Mechanism-of-action

• non- steroid topical immunosuppressive agent
• suppresses release of cytokines from T-cells & mast cells
• IL-2 inhibitor ?

Notes

• Manufacturer: Novaritis

More General Terms

• immunosuppressive agent

Additional Terms

• atopic dermatitis (eczema)

References

1. Prescriber's Letter 9(2):S1 2002
2. Prescriber's Letter 9(3):13 2002
3. Journal Watch 22(16):128, 2002 Wahn U et al Pediatrics 110:e2, 2002
4. Prescriber's Letter 12(4): 2005 FDA Public Health Advisory Elidel (pimecrolimus) Cream and Protopic (tacrolimus) Ointment Detail-Document#: [1] (subscription needed) [2] [3]
5. Journal Watch 25(9):75, 2005 Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials. BMJ. 2005 Mar 5;330(7490):516. Epub 2005 Feb 24. Review. <PubMed> PMID: [4] <Internet> [5]
6. FDA Medwatch [6]

pimecrolimus (Elidel)