Phosphatidylinositol Glycan Biosynthesis Class T Protein

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 More General Terms 6 Internet Database 7 References

Function

• component of the GPI transamidase complex
• essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates
• glycolipid biosynthesis; GPI-anchor biosynthesis
• the disulfide bond between PIGK/ GPI8 & PIGT is important for normal enzyme activity
• forms a complex with PIGK/ GPI8, PIGS, PIGU & GPAA1/ GAA1
• role in maintaining the complex by stabilizing expression of GPAA1 & GPI8 & linking them to PIGS

Structure

• belongs to the PIGT family

Compartment

• endoplasmic reticulum membrane
• single-pass type 1 membrane protein

Alternative-splicing

• named isoforms=4

More General Terms

• phosphatidylinositol-glycan biosynthesis protein (PIG-protein)
• membrane protein
• glycoprotein

Internet Database

Entrez gene: 51604
Kegg: [1]
OMIM: 610272
UniProt: [2]

References

UniProt [3]

GPI transamidase component PIG-T; phosphatidylinositol-glycan biosynthesis class T protein (PIGT)