Phensuximide

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Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Laboratory 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename: Milontin.

Indications

• seizures

Dosage

• 500-1000 mg PO BID/ TID

• Tabs: 500 mg

Pharmacokinetics

• rapidly absorbed
• metabolized in liver to active N-desmethyl derivative
  

• elimination via liver
• elimination via kidney
• 1/2life = 4 hours
• protein binding = <5 %
• elimination by hemodialysis = -
• elimination by hemoperfusion = -
• elimination by peritoneal dialysis = -

Adverse-effects

• nausea/vomiting
• anorexia
• headache
• fatigue
• lethargy
• dizziness
  
• drug adverse effects of anticonvulsants

Drug-interactions

• agents which increase phensuximide metabolism

• carbamazepine
• phenobarbital
• phenytoin
• primidone

• valproic acid may increase or decrease phensuximide concentration

Laboratory

• specimen: serum, plasma ( heparin, EDTA)
• methods: GLC, HPLC

More General Terms

• succinimide
• anticonvulsant

Internet Database

PubChem: 6839

References

1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 450
2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

phensuximide (Milontin)