Peroxisome

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Contents 1 Introduction 2 More General Terms 3 Additional Terms 4 Internet Database 5 References

Introduction

• Peroxisomes or microbodies contain enzymes that oxidize D-amino acids, uric acid & various 2-OH fatty acids using O2 with formation of H2O2. Catalase present in microsomes can dismutate H2O2 to O2 & H2O, & catalyze oxidation of various compounds by H2O2.

• Peroxisomes also contain enzymes involved in lipid metabolism, particularly the oxidation of very long chain fatty acids & the synthesis of glycerolipids & plasmalogens.
• Microbody proteins are synthesized on free polysomes & imported post-translationally. Unlike import of proteins into mitochondria, chloroplasts or the ER/ secretory pathway, import into microbodies does not generally require the removal of a presequence, but in part relies on the microbody C-terminal targeting signal ( CMTS).
• Zellweger syndrome is a result of an absence of peroxisomes.

More General Terms

• organelle

Additional Terms

• microbody-targeting signal or peroxisomal-targeting sequence
• peroxisomal disorder
• peroxisomal membrane protein (peroxin)
• peroxisome proliferator
• peroxisome proliferator-activated receptor (PPAR)

Internet Database

Prosite: [1]

References

1. Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 21
2. prosite [2]

peroxisome