Perk Protein Kinase

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• phosphorylates alpha subunit of eukaryotic translation- initiation factor 2 ( eIF2)

• results in inactivation of eIF2
• rapid reduction of translational initiation
• repression of global protein synthesis

• effector of unfolded protein response
• induces G1 growth arrest due to the loss of cyclin D1
• forms dimers with HSPA5/ BIP in resting cells
• dissociates from HSPA5/ BIP & oligomerizes in ER-stressed cells
• interacts with DNAJC3
• autophosphorylated

Structure

• N-glycosylated
• the lumenal domain senses perturbations in protein folding in the ER, probably through reversible interaction with HSPA5/ BIP
• belongs to the protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
• contains 1 protein kinase domain

Compartment

• endoplasmic reticulum

Expression

• ubiquitous
• induction by ER stress

Pathology

• defects are the cause of Wolcott-Rallison syndrome

More General Terms

• serine/threonine kinase
• glycoprotein
• membrane protein

Internet Database

OMIM: 226980
OMIM: 604032
Prosite: [1]
Prosite: [2]
Prosite: [3]
UniProt: [4]

References

1. UniProt [5]

eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; pancreatic eIF2-alpha kinase; HsPEK (EIF2AK3, PEK, PERK)