Pentosan Polysulfate

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Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Drug-interactions 7 Mechanism-of-action 8 More General Terms 9 Internet Database 10 References

Introduction

• Tradename: Elmiron.

Indications

• relief of bladder pain or discomfort due to interstitial cystitis

Dosage

• 100 mg PO TID
• take with water 1 hour prior to meals or 2 hours after meals
• re-evaluate therapy in 3 months
• discontinue if no improvement in 6 months

• Capsule: 100 mg.

Pharmacokinetics

• 3 to 6 months of therapy may be required before benefits are observed
  

• elimination via kidney

Adverse-effects

• not common (1-10%)

• headache, dizziness, alopecia, rash, diarrhea, nausea, dyspepsia, abdominal pain, abnormal liver function tests

• uncommon (< 1%)

• pruritis, urticaria, photosensitivity, bruising, vomiting, mouth ulcer, colitis, esophagitis, gastritis, flatulence, constipation, anorexia, gum bleeding, anemia, increased prothrombin time, increased partial thromboplastin time, leukopenia, thrombocytopenia, conjunctivitis, optic neuritis, amblyopia, retinal hemorrhage, tinnitus, pharyngitis, rhinitis, epistaxis, dyspnea, allergic reactions

• bleeding complications may occur in patients at increased risk

Drug-interactions

• no information available
• it is expected that effects may compound those of heparin, warfarin, aspirin & thrombolytic agents

Mechanism-of-action

• low molecular weight heparin-like compound with anticoagulant & fibrinolytic effects

More General Terms

• polysaccharide (complex carbohydrate, glycan)
• analgesic (antalgic)

Internet Database

PubChem: 37720
PubChem: 4738

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Kaiser Permanente Northern California Regional Drug Formulary, 1998

pentosan polysulfate (Elmiron, PPS, polypentose sulfate)