Pegademase

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Pharmacokinetics 4 Mechanism-of-action 5 More General Terms 6 References

Indications

• enzyme replacement therapy for patients with severe combined immunodeficiency disease ( SCID) due to adenosine deaminase ( ADA) deficiency

Dosage

• dosage individualized based on monitoring of plasma ADA activity
• weekly IM administration
  

• Injection: 250 units/ mL

Pharmacokinetics

• peak plasma levels of ADA activity reached 2-3 days following IM administration
• plasma elimination half-life of ADA following IM administration of Adagen is 3 to > 6 days

Mechanism-of-action

• (monomethoxypolyethylene glycol succinimidyl) 11-17- adenosine deaminase
• conjugate of numerous strands of monomethoxypolyethylene glycol covalently attached to the enzyme adenosine deaminase

More General Terms

• metabolic agent (metabolic modifier)

References

1. Adagen (pegademase bovine) injection [1]

pegademase bovine (Adagen)