P Glycoprotein
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Contents |
More Specific Terms
- ATP-binding cassette sub-family C member 12 (ATP-binding cassette C12, multidrug resistance-associated protein 9, ATP-binding cassette transporter sub-family C member 12, ABCC12, MRP9)
- P-glycoprotein 1 (PGY1, multidrug resistance protein 1, MDR1, gp170, ATP-binding cassette subfamily B member 1, ABCB1)
- P-glycoprotein 2 or multidrug resistance protein 2
- P-glycoprotein 3 (PGY3, multidrug resistance protein 3, MDR3, ATP-binding cassette subfamily B member 4, ABC4)
Function
- P-glycoprotein 1 helps eliminate drugs by pumping them OUT of cells, back into the gut, bile, & urine for excretion
- P-glycoprotein 3 transports phosphatidylcholine
Pathology
- tumor cells may up-relate P-glycoprotein 1 as a mechanism for development of resistance to antineoplastic agents
More General Terms
- transmembrane 12 protein
- adenosine triphosphatase (ATPase)
- glycoprotein
- carrier protein (transporter)
Internet Database
Prosite: [1]
