P2x7 Purinoceptor

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• receptor for ATP
• acts as a ligand gated ion channel
• role in ATP-dependent lysis of macrophages via formation of membrane pores permeable to large molecules
• may function in both fast synaptic transmission & ATP-mediated lysis of antigen-presenting cells
• interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 & PTPRB
• phosphorylation results in its inactivation

Structure

• belongs to the P2X receptor family
• forms homo- or heteropolymers

Compartment

• membrane

More General Terms

• transmembrane 2 protein
• P2X purinoceptor or P2X purinergic receptor
• phosphoprotein
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 602566
Prosite: [2]
UniProt: [3]
Entrez gene: 5027

References

1. UniProt [4]
2. Wikipedia; Note: P2X receptor entry [5]
3. Wikipedia; Note: P2RX7 entry [6]

P2X7 purinoceptor; P2X purinoceptor 7; P2X7; ligand-gated ion channel purinergic receptor P2X7; P2Z receptor (P2RX7)