Oxtriphylline

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Contraindications 4 Dosage 5 Pharmacokinetics 6 Adverse-effects 7 Drug-interactions 8 Mechanism-of-action 9 More General Terms 10 Additional Terms 11 Internet Database 12 References

Introduction

• Tradename: Choledyl. (61% anhydrous theophylline).

Indications

• symptomatic treatment of asthma & reversible bronchospasm

Contraindications

• uncontrolled arrhythmias

• Caution:

• peptic ulcer disease
• hyperthyroidism
• congestive heart failure
• COPD
• liver disease

• pregnancy-category C
• safety in lactation ?

Dosage

• adults: 4.7 mg/kg PO TID; administer sustained release every 12 hours
• children:

• 1-9 years: 6.2 mg/kg every 6 hours
• 9-16 years: 4.7 mg/kg every 6 hours

• Tabs: 100 & 200 mg.
• Sustained release: 400 mg, 600 mg.
• Elixir: 50 & 100 mg/5 mL.
• Sustained action: Choledyl SA:

• 400-600 mg PO BID

• Tabs: 400 & 600 mg.

Pharmacokinetics

• elimination: liver

Adverse-effects

• not common (1-10%)

• tachycardia, nervousness, restlessness, nausea/vomiting

• uncommon (< 1%)

• insomnia, irritablity, seizures, rash, gastric irritation, tremor, allergic reaction

Drug-interactions

• smoking alters metabolism
• cimetidine & possibly ranitidine
• rifampin
• phenytoin
• barbiturates
• ciprofloxacin
• erythromycin
  
• drug interaction(s) of lithium carbonate with xanthine

Mechanism-of-action

• bronchodilator

More General Terms

• methylxanthine
• antiasthmatic agent
• pharmacologic combination

Additional Terms

• asthma

Internet Database

PubChem: 656652
PubChem: 20585

References

1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 628
2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

oxtriphylline [choline theophyllinate] (Choledyl)