Osteoblast
From Anvita Health Wiki
Introduction
- Function:
- bone formation
- production of osteoid containing collagen type 1
- mineralization of osteoid matrix
- remodeling of bone in conjunction with osteoclasts
- osteoblasts trapped in the bone matrix become osteocytes
- Formation:
- differentiation induced by bone morphogenic proteins
- other growth factors may be involved
- Markers:
- osteoprogenitor cells express Cbfa1/ Runx2
- osteoblasts express osterix, col1, ALP, osteocalcin, osteopontin, osteonectin
- Regulation of osteoclasts by RANKL, cell surface & secreted
- Morphology:
- cytoplasm is basophilic on H&E stain due to presence of large amounts of rough endoplasmic reticulum
- nucleus is large & spherical
- stain positively for collagen tyep 1 of alkaline phosphatase
More General Terms
References
Wikepedia, The Free Encyclopedia [1]
