Origin Of Replication

From Anvita Health Wiki

Contents 1 Introduction 2 Function 3 Structure 4 More General Terms 5 Additional Terms 6 References

Introduction

• origins of replication are typically assigned names containing ori

Function

• sequence in a genome at which replication is initiated
• binds origin of replication complex which, with help from two further protein factors ( Cdc6 & Cdt1), load the minichromosome maintenance protein complex
• once assembled, pre-replication complex unwinds, & begins to copy DNA
• DNA replication may proceed from this point bidirectionally or unidirectionally
• eukaryotes often have multiple origins of replication on each linear chromosome, with up to 100,000 present in a single human cell [2]
• many origins of replication shortens time of DNA replication
• the segment of DNA that is copied starting from each unique replication origin is called a replicon

Structure

• AT rich DNA
• DNA sequences at the replication origins vary
• despite this sequence variation, all the origins form a base for assembly of the origin of replication complex

More General Terms

• biochemistry

Additional Terms

• origin of replication complex (origin recognition complex, ORC)
• replicon

References

1. WikiPedia: Origin of Replication [1]
2. Nasheuer HP, Smith R, Bauerschmidt C, Grosse F, Weisshart K Initiation of eukaryotic DNA replication: regulation and mechanisms. Prog. Nucleic Acid Res. Mol. Biol. (2002) 72: 41-94. PMID: [2]

origin of replication