Ob Receptor

Function

receptor for leptin ( obesity factor)
on ligand binding, mediates signaling through JAK2/ STAT3
role in regulation of fat metabolism &, in a hematopoietic pathway, required for normal lymphopoiesis
may play a role in reproduction
able to mediate the ERK/ FOS signaling pathway ( putative)
on leptin stimulation, homodimerizes
on leptin binding, phosphorylated on 2 conserved C-terminal Tyr ( isoform B only) by JAK2
phosphorylated receptor binds a number of SH2 domain- containing proteins including STAT3, PTPN11, & SOCS3 ( putative)
interaction with SOCS3 inhibits LRb signaling ( putative)
Tyr-986 is required for complete binding & activation of PTPN11, ERK/ FOS activation &, for interaction with SOCS3 ( putative)
phosphorylation on Tyr-1141 is required for STAT3 binding & activation

cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase & STATs
WSXWS motif appears to be necessary for proper protein folding & thus efficient intracellular transport & cell-surface receptor binding
box 1 motif is required for JAK interaction &/or activation
belongs to the type I cytokine receptor family, type 2 subfamily
contains 4 fibronectin F3 modules
contains 1 Ig-like (immunoglobulin-like) domain

isoform A is expressed in fetal liver & in hematopoietic tissues & choroid plexus
in adults highest expression in heart, liver, small intestine, prostate & ovary
low level in lung & kidney
isoform B is highly expressed in hypothalamus
arcuate nucleus of hypothalamus [2]
POMC & neuropeptide Y neurons

Kegg: [1]
OMIM: 601007
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
Entrez gene: 3953

Tartaglia LA et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-71 1995 PMID: [6]
Cowley MA et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-4, 2001 PMID: [7]
UniProt [8]