Nuclear Receptor Coactivator 2

Function

transcriptional coactivator for steroid receptors & nuclear receptors
coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain ( AF-1)
required with NCOA1 to control energy balance between white & brown adipose tissues
phosphorylated upon DNA damage, probably by ATM or ATR
present in a complex containing CARM1 & EP300/P300, & interacts with CARM1 & NR3C2 ( putative)
present in a complex containing NCOA3, IKKA, IKKB, IKBKG & CREBBP
interacts (via C-terminus) with CREBBP
interacts with HIF1A, NCOA1, APEX & NR3C1
interacts with CASP8AP2 & TTLL5/ STAMP
interacts with ESR1, RARA & RXRA
interacts with PSMB9

contains four Leu-Xaa-Xaa- Leu- Leu (LXXLL) motifs
the LXXLL motifs are essential for the association with nuclear receptors & are, at least in part, functionally redundant
the LLXXLXXXL motif is involved in transcriptional coactivation & CREBBP/ CBP binding
contains 2 C-terminal transcription activation domains ( AD1 & AD2) that can function independently
belongs to the SRC/ p160 nuclear receptor coactivator family
contains 1 basic helix-loop-helix (bHLH) domain
contains 1 PAS (PER-ARNT-SIM) domain

chromosomal inversion inv(8)(p11;q13) involving NCOA2 may be a cause of acute myeloid leukemias
the inversion generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/ MOZ & the C-terminus part of NCOA2/TIF2
MYST3-NCOA2 binds to CREBBP & disrupts its function in transcription activation

Entrez gene: 10499
Kegg: [1]
OMIM: 601993
Prosite: [2]
Prosite: [3]
UniProt: [4]