Norepinephrine Transporter

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 Pathology 6 More General Terms 7 Internet Database 8 References

Function

• amine transporter
• terminates the action of noradrenaline by its high affinity Na+-dependent reuptake into presynaptic terminals
• interacts with PRKCABP

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

• membrane

Expression

• a 5.8 kB mRNA transcript is localized to adrenal medulla & locus ceruleus norepinephrine neurons
• a 3.6 kB mRNA transcript is ubiquitously expressed
• may be cross hybridization or glial-specific form

Pathology

• defects in SLC6A2 are a cause of orthostatic intolerance

More General Terms

• solute carrier family 6
• adenosine triphosphatase (ATPase)
• glycoprotein

Internet Database

Kegg: [1]
OMIM: 163970
OMIM: 604715
Prosite: [2]
Prosite: [3]
Prosite: [4]
UniProt: [5]
Entrez gene: 6530

References

1. UniProt [6]
2. GeneReviews [7]
3. Pacholczyk et al Expression cloning of a cocaine- and antidepressant- sensitive human noradrenaline transporter. Nature 350:350 1991 PMID: [8]

Na+ dependent noradrenaline transporter; norepinephrine transporter; NET; solute carrier family 6 member 2 (SLC6A2, NAT1, NET1, SLC6A5)