Nitrate

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Contents 1 More Specific Terms 2 Classification 3 Pharmacology 4 Indications 5 Adverse-effects 6 Notes 7 More General Terms 8 Additional Terms 9 Internet Database 10 References

More Specific Terms

• isosorbide dinitrate (Isordil, Sorbitrate, Isordil Tembids, Dinitrate SR, ISDN)
• isosorbide mononitrate (ISMO, Monoket, Imdur)
• nitroglycerin; NTG; TNG (Tridil, NitroBid, Nitrol, Nitrostat, Deponit, Minitran, NitroDur, Nitropaste, Rectiv)

Classification

• nitroglycerin
• isosorbide dinitrate
• isosorbide mononitrate

Pharmacology

• A drug whose metabolites produce a relaxation of vascular smooth muscle. This in turn produces a strong dilation of the veins, reducing preload, wall tension & myocardial oxygen demand.

Indications

• angina pectoris
• acute myocardial infarction
• heart failure

• Nitrates may also reduce risk of bleeding peptic ulcers.

Adverse-effects

• hypotension in patients with reduced preload

• usually responsive to
• volume expansion
• dose reduction

• headache

Notes

• Nitrate tolerance may occur with continuous exposure.

More General Terms

• vasodilator agent

Additional Terms

• NO3- (nitrate)

Internet Database

PubChem: 944

References

1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 87-88
2. Journal Watch 20(18):144, 2000
3. Prescriber's Letter 17(3): 2010 Comparison of Nitrate Products Detail-Document#: [1] (subscription needed) [2]

nitrate