Nitisinone

From Anvita Health Wiki

Contents 1 Indications 2 Dosage 3 Monitor 4 Adverse-effects 5 More General Terms 6 References

Indications

• adjunct to dietary restriction of tyrosine & phenylalanine in the treatment of hereditary tyrosinemia type 1

Dosage

• 1-2 mg/kg divided into two daily doses
  

• Capsules: 2 mg, 5 mg, 10 mg

Monitor

• serum alpha-fetoprotein
• monitor liver with hepatic ultrasound, CT or MRI

Adverse-effects

• thrombocytopenia
• leukopenia
• acute porphyria
• ocular/visual complaints, transient resolving within 1 week
• hepatic neoplasm
• liver failure

More General Terms

• metabolic agent (metabolic modifier)

References

1. RxList [1]

nitisinone (Orfadin)