Nicotinic Receptor Alpha 9

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• nicotinic receptor alpha subunit
• subunit of ionotropic receptor with probable role in modulation of auditory stimuli
• channel associated with receptor is permeable to a range of divalent cations including Ca+2, the influx of which may activate a K+ current which hyperpolarizes the cell membrane
• in the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers & reducing the range of dynamic hearing
• this may protect against acoustic trauma
• may also regulate keratinocyte adhesion
• can form homo- or hetero- oligomeric channels in conjunction with CHRNA10
• the native outer hair cell receptor may be composed of CHRNA9- CHRNA10 hetero- oligomers
• the CHRNA9- CHRNA10 hetero-oligomer has an atypical pharmacological profile, binding several non-nicotinic ligands including:

• strychnine (glycine receptor antagonist)
• atropine ( muscarinic acetylcholine receptor antagonist)

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Expression

• expressed in cochlea, keratinocytes, pituitary gland, B-cells & T-cells

More General Terms

• nicotinic receptor alpha

Internet Database

Kegg: [1]
OMIM: 605116
Prosite: [2]
UniProt: [3]

References

UniProt [4]

nicotinic receptor alpha-9; neuronal acetylcholine receptor subunit alpha-9; nicotinic acetylcholine receptor subunit alpha 9; NACHR alpha 9 (CHRNA9, NACHRA9)