Nicotinic Receptor Alpha 10

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Expression 5 More General Terms 6 Internet Database 7 References

Function

• nicotinic receptor alpha for ionotropic receptor with a probable role in the modulation of auditory stimuli
• the channel is permeable to a range of divalent cations including Ca+2, the influx of which may activate a K+ current which hyperpolarizes the cell membrane
• in the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers & reducing the range of dynamic hearing
• this may protect against acoustic trauma
• forms hetero- oligomeric channels in conjunction with CHRNA9
• the native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero- oligomers
• the hetero- oligomeric receptor composed of CHRNA9 & CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including:

• strychnine (glycine receptor antagonist)
• atropine ( muscarinic acetylcholine receptor antagonist)

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Expression

• expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells & peripheral blood lymphocytes

More General Terms

• nicotinic receptor alpha

Internet Database

Kegg: [1]
OMIM: 606372
Prosite: [2]
UniProt: [3]

References

UniProt [4]

nicotinic receptor alpha-10; neuronal acetylcholine receptor subunit alpha-10; nicotinic acetylcholine receptor subunit alpha 10; NACHR alpha 10 (CHRNA10, NACHRA10)