Nedocromil

From Anvita Health Wiki

Contents 1 Introduction 2 Indications 3 Dosage 4 Pharmacokinetics 5 Adverse-effects 6 Mechanism-of-action 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename: Tilade, Alocril (ophthlamic)

Indications

• prophylaxis for allergen-induced asthma
• prophylaxis for exercise-induced asthma

• inhaler 15-20 minutes before exercise

• allergic conjunctivitis

Dosage

• inhaler:

• 2 puffs QID, 1.75 mg/activation (16.2 g)

• ophthalmic:

• 2%, pH 4.0-5.5%, osmolality 270-330 mOsm/kg [5]

Pharmacokinetics

• no significant systemic absorption ( ophthalmic)
  

• elimination via liver

Adverse-effects

• not common (1-10%)

• coughing, pharyngitis, rhinitis, bronchitis, dyspnea, bronchospasm, nausea/vomiting, dry mouth, diarrhea, dizziness, headache, chest pain, fatigue, taste disturbance

Mechanism-of-action

• inhibits mast cell response to IgE

• 4 to 10 times more powerful than cromolyn

• inhibits activation of macrophages
• inhibits activation of T helper cells
• decreases bronchial hyper-responsiveness
• decreased chemotaxis of eosinophils

More General Terms

• quinolone
• mast cell stabilizer
• antiasthmatic agent

Internet Database

PubChem: 50294
PubChem: 50295
PubChem: 68731

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 742
3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
4. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
5. Alocril [1]

nedocromil (Tilade, Alocril)