Necrosis
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Contents |
More Specific Terms
- aseptic necrosis
- avascular necrosis (AVN)
- caseous necrosis
- coagulation necrosis
- colonic necrosis
- enzymatic fat necrosis
- eschar
- fibrinoid necrosis
- geographic necrosis
- hepatic necrosis
- liquifaction necrosis
- oncosis (ischemic cell death)
- radiation necrosis
- renal cortical necrosis
- renal papillary necrosis
- skin necrosis
Introduction
- Death of tissue.
Etiology
Pathology
- swelling & rupture of cell
- mitochochondria disintegrate
- ATP is depleted
- disintegration of other organelles
- induction of inflammatory process
Notes
- Necrosis contrasts with apoptosis by an early loss in membrane integrity, leakage of cytoplasmic contents & induction of the inflammatory process. Apoptosis is associated with changes in membrane permeability without membrane disinitegration & without induction of the inflammatory process. Necrosis is pathologic, whereas apoptosis can be pathologic or physiologic.
- Necrosis may involve massive activation of poly ADP-ribose polymerase & depletion of NAD & secondarily ATP. [1]
More General Terms
Additional Terms
References
- Sedlak TW, Snyder SH. Messenger molecules and cell death: therapeutic implications. JAMA. 2006 Jan 4;295(1):81-9. PMID: [1]
- Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer. 2004 Aug;4(8):592-603. Review. No abstract available. PMID: [2]
- Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004 Jan 23;116(2):205-19. Review. PMID: [3]
- Syntichaki P, Tavernarakis N. The biochemistry of neuronal necrosis: rogue biology? Nat Rev Neurosci. 2003 Aug;4(8):672-84. Review. No abstract available. PMID: [4]
- Syntichaki P, Tavernarakis N. Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep. 2002 Jul;3(7):604-9. PMID: [5]
