Nabumetone

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Contents 1 Introduction 2 Indications 3 Dosage 4 Monitor 5 Adverse-effects 6 Mechanism-of-action 7 More General Terms 8 Internet Database 9 References

Introduction

• Tradename: Relafen.

Indications

• osteoarthritis
• rheumatoid arthritis

Dosage

• 1-2 g PO QD or divided BID

• Tabs: 500, 750 mg.

Monitor

• liver function tests periodically [5]
  
• monitor with non steroidal anti-inflammatory agents (NSIADs)

Adverse-effects

• may be less nephrotoxic than other NSAIDs because it is metabolized to inactive metabolites before excretion into the urine [3]
  
• drug adverse effects of NSAIDs

Mechanism-of-action

• inhibits cyclooxygenase, some selectivity for COX-2 [4]

More General Terms

• non-steroidal anti-inflammatory agent (NSAID)

Internet Database

PubChem: 4409

References

1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
2. Kaiser Permanente Northern California, Drug update, 9/2000
3. Prescriber's Letter 10(5):29 2003
4. Prescriber's Letter 12(3): 2005
5. Prescriber's Letter 17(7): 2010 Recommended Lab Monitoring for Common Medications Liver Function Test Scheduling Detail-Document#: [1] (subscription needed) [2]

nabumetone (Relafen)