Na+ Dependent Vitamin C Transporter 1

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Alternative-splicing 5 Expression 6 More General Terms 7 Internet Database 8 References

Function

• Na+/ ascorbate cotransporter. mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate
• phosphorylated (probable)

Structure

• belongs to the xanthine/ uracil permease family, SLC23A subfamily

Compartment

• membrane

Alternative-splicing

• named isoforms=3

Expression

• highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate & liver, & in fetal kidney, liver & thymus
• treatment with the protein kinase C stimulator PMA results in a 10-fold decrease in ascorbate accumulation in transfected cells

More General Terms

• symporter
• glycoprotein
• solute carrier family 23 (SLC23, SLC23A)

Internet Database

Kegg: [1]
OMIM: 603790
UniProt: [2]

References

UniProt [3]

solute carrier family 23 member 1; Na+ dependent vitamin C transporter 1; hSVCT1; Na+/L-ascorbic acid transporter 1; yolk sac permease-like molecule 3 (SLC23A1, SVCT1, YSPL3)