Na+/k+/ca+2 Exchanger 5

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 Polymorphism 5 More General Terms 6 Internet Database 7 References

Function

• cation exchanger involved in pigmentation
• role in ion transport in melanosomes
• transports 1 Ca+2 & 1 K+ in exchange for 4 Na+

Structure

• belongs to the sodium/ potassium/ calcium exchanger family, SLC24A subfamily

Compartment

• membrane, melanosome
• enriched in late-stage melanosomes

Polymorphism

• Ala-111 allele predominates (93-100%) in African & East Asian populations
• Thr-111 allele predominates (98.7-100%) in European populations, correlates with lighter skin pigmentation in mixed populations

More General Terms

• solute carrier family 24 (SLC24, SLC24A)
• transmembrane 11e protein

Internet Database

UniProt: [1]

References

1. UniProt [2]
2. Protein Spotlight, Skin-deep - Issue 74 of September 2006 [3]

Na+/K+/Ca+2 exchanger 5 (solute carrier family 24 member 5, SLC24A5 JSX NCKX5)