N Acetylglucosaminyltransferase 3

From Anvita Health Wiki

Contents 1 Function 2 Structure 3 Compartment 4 More General Terms 5 Internet Database 6 References

Function

• role in regulation of biosynthesis & biological function of glycoprotein oligosaccharides
• catalyzes addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains
• protein modification; protein glycosylation

* UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R 
*              <--> 
* UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R

Structure

• belongs to the glycosyltransferase 17 family

Compartment

• Golgi membrane

More General Terms

• glycosyltransferase
• glycoprotein
• membrane protein
• phosphoprotein

Internet Database

UniProt: [1]
Entrez gene: 4248
Kegg: [2]
OMIM: 604621

References

1. UniProt [3]
2. GGDB; Note: Glycogene database [4]
3. Functional Glycomics gateway - GTase beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyl- transferase [5]

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; N-acetylglucosaminyltransferase III; GlcNAc-T III; GNT-III (MGAT3, GGNT3)