Monoamine Oxidase Inhibitor

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Contents 1 More Specific Terms 2 Indications 3 Contraindications 4 Adverse-effects 5 More General Terms 6 References

More Specific Terms

• isocarboxazid (Marplan)
• L-deprenyl (Selegiline, Eldepryl, Emsam, Zelapar)
• moclobemide (Aurorix, Manerix)
• phenelzine (Nardil, Sinerval)
• rasagiline (Azilect)
• tranylcypromine (Parnate)

Indications

• treatment of major depression*

Contraindications

• Caution:
• the sometimes severe & unpredictable interactions of MAO inhibitors with other drugs has favored use of other antidepressants

Adverse-effects

• Toxicity:

• Manifestations:

• CNS stimulation, fever, tachycardia, tachypnea, hypertension, nausea, vomiting, dilated pupils, nystagmus, papilledema.

• Treatment:

• GI decontamination, activated charcoal, cathartics.
• Dantrolene (2.5 mg/kg PO or IV every 6 for hyperthermia.
• Nitroprusside for hypertension
• Propranolol for tachycardia
• Fluids for hypotension
• Benzodiazepines for seizures
  

• drug adverse effects of MAO inhibitors
• drug adverse effects of antidepressants

More General Terms

• enzyme inhibitor
• antidepressant

References

1. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990, pg 414
2. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 134.

monoamine oxidase [MAO] inhibitor